Multiplex FISH analysis |
Does the karyotype show any abnormalities? Which chromosome(s) is/are involved? |
What common name is given to this abnormality? |
Consider the two cytogenetic and mFISH techniques in the context of this patient’s case. What are the advantages / disadvantages to each technique? |
Questions to be answered from the article |
Give a brief overview of the discovery of this defect. |
Which genes are affected? |
What are the possible consequences of this abnormality? |
What is the common molecular feature of this abnormality? Suggest a method you might use to test for this feature. |
Formal report |
Write a report on this case study, in the format of a journal article. |
A good report will incorporate ALL the questions you have answered in this handout, in the appropriate sections (ie. “Introduction” “Methods” “Results” “Discussion”). The Methods section should make reference to the patient details and the methods used to investigate the case. |
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